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2021

Ganzen L, Ko MJ, Zhang M, Xie R, Chen L, Zhang L, James R, Mumm J, Van Rijn RM, Zhong W, Pang CP, Zhang M, Tsujikawa M, Leung YF, Drug Screening with Zebrafish behavior identifies Carvedilol as a potential treatment for Retinitis Pigmentosa, BioRxiv preprint,  https://doi.org/10.1101/2020.07.28.225789

Sharma K, Cassell R, Su H, Blaine A, Cummins B, Mores K, Johnson D, Van Rijn R, Altman R, Modulating beta-arrestin-2 recruitment at the delta and mu opioid receptor, ChemRxiv https://doi.org/10.26343/chemrxiv.12685928.v1


Ko MJ, Chiang T, Mukadam AA, Mulia, GE, Gutridge AM, Lin A, Chester JA, Van Rijn RM, β-arrestin-dependent ERK signaling positively correlates with reduced anxiety-like and conditioned fear-related behavior in mice, Sci Signaling accepted for publication, https://doi.org/10.1101/790568v2 ​

Bertels Z, Witkowski W, Asif, S, Siegersma K, Van Rijn RM, Pradhan AA, A non-convulsant DOR agonist, KNT-127, reduces cortical spreading depression and nitroglycerin induced allodynia, Headache, in press

Creed SM (1), Gutridge AM (1), Argade MD, Hennessy MR, Brent Friesen JJB, Pauli GF, van Rijn RM, Riley AP, Isolation and Pharmacological Characterization of six Opioidergic Picralima nitida Alkaloids, J Natural Products, 2021, 84(1): 71-80

Ding Z, Knipp GT, Van Rijn RM, Chester JA, Watts VJ, The CUL3/neddylation inhibitor MLN4924 reduces inflammatory pain allodynia and ethanol-induced locomotor sensitization in mice, Behavioural Brain Research, 2021, 399, 113051:1-5

2020

Gutridge AM (1), Robins MT (1), Cassell RJ (1), Uprety R(1), Mores KL, Ko MJ, Pasternak G, Majumdar S, Van Rijn RM, Kratom reduces alcohol consumption in mice through a mechanism that relies on G protein-biased delta opioid receptor activation. Br J Pharmacol, 2020, 177(7): 1497-1513

2019

Cassell RJ (1), Sharma KK (1), Su H, Cummins BR, Cui H, Mores KL, Altman RA, Van Rijn RM, The meta-position of Phe4 in Leu-enkephalin regulates potency, selectivity, functional activity, and signaling bias at the delta and mu opioid receptors, Molecules, 2019, 24, 4542: 1-15

Cai B, Kim D, Akhand S, Sun Y, Cassell RJ, Alpsoy A, Dykhuizen EC, Van Rijn RM, Wendt MK, Krusemark CJ, (2019), Selection of DNA-encoded Libraries to Protein Targets Within and On Living Cells. J Am Chem Soc, 141: 17057-17061


Mores KL (1), Cummins BR (1), Cassell RJ, Van Rijn RM, (2019) A review of the therapeutic potential of recently developed G protein-biased kappa agonists, Front Pharmacol, 10(407):1-14

Mores KL, Cassell RJ, Van Rijn RM, (2019) Arrestin recruitment and signaling by G protein-coupled receptor heteromers, Neuropharmacology​, 152:15-21 

Ko MJ (1), Mulia GE (1), Van Rijn RM (2019) Commonly used anesthesia/euthanasia methods for brain collection differentially impact MAPK activity in male and female C57BL/6 mice, Front Cell Neurosci, 13(96):1-10

Ko MJ, Van Rijn RM (2019) Response: Commentary: Commonly used anesthesia/euthanasia methods for brain collection differentially impact MAPK activity in male and female C57BL/6 mice, Front Cell Neurosci, 13(379):1-2

Robins MT, Blaine AT, Ha JE, Brewster AL, Van Rijn RM, (2019) Repeated use of the psychoactive substance ethylphenidate impacts neurochemistry and reward learning in adolescent male and female mice, Front Neurosci, 13 (124): 1-14

Ko MJ(1), Ganzen L (1), Coskun E, Mukadam AA, Lueng YF, Van Rijn RM, (2019) Critical evaluation of TRPA1-mediated locomotive behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery, Sci Rep, 9 (2430): 1-11

Cassell RJ (1), Mores KL (1), Zerfas BL, Mahmoud, AH, Lill MA, Trader TJ, Van Rijn RM, (2019) Rubiscolins at naturally occuring G protein-biased delta opioid receptor peptides, Eur Neuropsychopharmacol, 29 (3): 450-456


Kaur J, Soto-Velasquez M, Ding Z, Van Rijn RM, Watts VJ, Flaherty DP,  (2019) Optimization of a 1,3,4-oxadiazole series for inhibition of adenylyl cyclase 1 and 8 for the treatment of chronic pain, Eur J Med Chem, 162: 568-585 

2018

Alongkronrusmee D, Watts VJ, Van Rijn RM (2018), Bimolecular fluorescence complementation methodology to study G protein-coupled receptor dimerization in living cells, Neuromethods, 140, 205-​221

​Robins MT, Chiang T, Mores KL, Alongkronrusmee, D, Van Rijn RM, (2018) Critical role for Gi/o-protein activity in the dorsal striatum in the reduction of voluntary alcohol intake in C57BL/6 mice, Front. Psychiatry (special topic in opioid research), 9 (112):1-14 

Robins MT, Chiang T, Berry JN, Ko MJ, Ha JE, Van Rijn RM, (2018) Behavioral characterization of beta-arrestin1 knockout mice in anxiety-like and alcohol behaviors, Front. Behav. Neurosci, 12 (54):1-11

Marquez-Gomez R, Robins MT, Guitierrez-Rodelo C, Arias JM, Olivares-Reyes JA, Van Rijn RM, Arias-Montano JA, (2018) Functional histamine H3 and adenosine A2a receptors in recombinant cells and rat striatum, Pharmacol Res, 129:515-525

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Alongkronrusmee D, Chiang T, Van Rijn RM (2018). Delta opioid pharmacology in relation to alcohol behaviors. Handb Exp Pharmacol, 247: 199-225

2017

​Burst TF, Alongkronrusmee D, Soto-Velasquez M, Baldwin TA, Ye Z, Dai M, Dessauer CW, van Rijn RM, Watts VJ (2017). Identification of a selective small molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Sci Signal, 10 (467)

Zeng L, Alongkronrusmee D, van Rijn RM (2017). An Integrated Perspective on Diabetic, Alcoholic, and Drug-Induced Neuropathy etiology and treatment in the United States. J Pain Res, 10: 219-228

2016

Anastasia AD, Selzer CC, Elentably H, Van Rijn RM, Krause JE (2016). Heroin use disoder - The evolving role of the pharmacist, Indiana Pharmacy Alliance continued education #5.

Alongkronrusmee D, Chiang T, Van Rijn RM (2016). Involvement of delta opioid receptors in alcohol withdrawal-induced mechanical allodynia in male C57Bl/6 mice. Drug and Alcohol Dependence, 167, 190-198

Yang S, Ben-Shalom R, Ahn M, Liptak AT, Van Rijn RM, Whistler JL, Bender KJ (2016). Beta-arrestin-dependent dopaminergic regulation of calcium channel activity in the axon initial segment. Cell Report, 16(6), 1518-1526
Robins MT, Lu J, Van Rijn RM (2016). Unique behavioral and neurochemical effects induced by repeated adolescent consumption of caffeine-mixed alcohol in C57BL/6 mice. PLOS ONE, 11(7):e0158189
Robins MT, DeFriel JN, Van Rijn RM (2016). Adolescent intake of caffeinated energy drinks does not affect adult alcohol consumption in C57BL/6 and BALB/c mice. Alcohol, 54, 1-9
Chiang T, Sansuk K, Van Rijn RM (2016). Beta-arrestin 2 dependence of delta opioid receptor agonists is correlated with alcohol intake. British Journal of Pharmacology, 173(2), 332-343

2013

Milan-Lobo L, Enquist J, van Rijn RM, Whistler JL (2013). Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism. PLOS One, 8(3) e58362.  

van Rijn RM, Defriel JN, Whistler JL (2013). Pharmacological traits of delta opioid receptors: pitfalls or opportunities? Psychopharmacology (Berl), 228(1) 1-18. 

Harvey JH, van Rijn RM, Whistler JL (2013). A FLIPR assay for evaluating agonists and antagonists of GPCR heterodimers. Methods Mol Biol, 995 43-54.

van Rijn RM, Harvey JH, Brissett DI, DeFriel JN, Whistler JL (2013). Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling. J Pharmacol Exp Ther, 344(1) 179-88.

2012

Brissett DI, Whistler JL, van Rijn RM (2012). Contribution of mu and delta opioid receptors to the pharmacological profile of kappa opioid receptor subtypes. Eur J Pain, 16(3) 327-37. 
 
van Rijn RM, Brissett DI, Whistler JL (2012). Distinctive modulation of ethanol place preference by delta opioid receptor-selective agonists. Drug Alcohol Depend, 122(1-2) 156-9.  

van Rijn RM, Brissett, DI, Whistler JL (2012). Emergence of functional spinal delta opioid receptors after chronic ethanol exposure. Biol Psychiatry, 71(3) 232-8.  

2010

van Rijn RM, Brissett DI, Whistler JL (2010). Dual efficacy of delta opioid receptor-selective ligands for ethanol drinking and anxiety. J Pharmacol Exp Ther, 335(1) 133-9.
  
van Rijn RM, Whistler JL, Waldhoer M (2010). Opioid-receptor-heteromer-specific trafficking and pharmacology. Curr Opin Pharmacol, 10(1) 73-9.  

2009

van Rijn RM, Whistler JL (2009). The delta(1) opioid receptor is a heterodimer that opposes the actions of the delta(2) receptor on alcohol intake. Biol Psychiatry, 66(8) 777-84. 

He L, Kim J, Ou C, McFadden W, van Rijn RM, Whistler JL (2009). Methadone antinociception is dependent on peripheral opioid receptors. J Pain, 10(4) 369-79

2008

van Rijn RM, Whistler JL (2008). The only way is up: preventing opioid tolerance by promoting cell surface expression of MOR-DOR heterodimers? Mol Interv, 8(6) 277-80.

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