The mission of the Van Rijn lab is to uncover new strategies to treat psychiatric and neurological disorders. We specifically investigate the heavily co-morbid triad of drug use disorders, chronic pain disorders and mood disorders. Our primary target, the delta opioid receptor, is involved in the neuropharmacology of all three disorders and thus offers an exciting novel approach to treat these disorders. The Van Rijn lab covers all aspects of preclinical drug development including drug synthesis, drug screening, pharmacological characterization both in vitro and in vivo. We also perform mechanistic studies to improve our understanding of the etiology of these disorders.
News - 2020
March 9th, 2020 - The St. Louis College of Pharmacy published a news release for the print publication of our kratom article in the British Journal of Pharmacology.
March 6th, 2020 - Congratulations to Anna Gutridge for winning 1st prize in the Purdue Health and Disease Poster session competition (Neuroscience and Neurodegenerative Disease category).
February 25th, 2020 - Arryn Blaine and Anna Gutridge have been awarded travel fellowships from the Purdue College of Pharmacy to present their research at the 2020 International Narcotics Research Conference in Valencia, Spain.
February 12th, 2020 - Mee Jung Ko and Anna Gutridge presented posters at the Sigma Xi poster session at Purdue University
February 11th, 2020 - A spotlight article in Trends in Pharmaceutical Sciences highlighted the DNA-encoded library assay recently published in a JACS paper we collaborated on with the Krusemark lab.
January 24th, 2020 - Dr. Van Rijn has started his sabbatical in the laboratory of Dr. Brian Shoichet in the Department of Pharmaceutical Chemistry at the University of California San Francisco. Dr. van Rijn will learn new skills in how to dock ultra-large virtual libraries at GPCRs, in particular the newly published agonist-bound DOR structures.
January 15th, 2020 - Mee Jung Ko, 5th year PULSe graduate student in the lab successfully defended her thesis "Molecular mechanisms of G protein-coupled receptor signaling in the modulation of anxiety, Fear and Pain" completing her final requirement in the program. Congratulations to Dr. Mee Jung Ko!!
Donate to science.
If you appreciate the research carried out in the Van Rijn lab and support our goals feel free to donate to the advancement of science. Donations will be used to help support (undergraduate) students and carry out experiments exploring exciting new preliminary projects, currently not funded through other mechanisms.
Donations can be made by specifically mentioning the Van Rijn lab at the following Purdue University website:
Purdue Research Foundation: Giving to Purdue
Instructions on types of donations
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December 9th, 2019 - Our paper "The meta-position of Phe4 in leu-enkephalin regulates potency, selectivity, functional activity and signaling bias at the delta and mu opioid receptors" has been accepted for publication in Molecules and will be part of the special issue: "Opioids and Their Receptors Present and Emerging Concepts in Opioid Drug Discovery"
October 16th, 2019 - A paper by the Krusemark lab "Selection of DNA-encoded Libraries to Protein Targets Within and On Living Cells" that we collaborated on has been accepted by the Journal of the American Chemical Society
October 15th, 2019 - Our paper "G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder" has been accepted for publication in the British Journal of Pharmacology
October 2nd, 2019 - We deposited our pre-print "beta-arrestin depedendent ERK signaling positively correlates with reduced anxiety-like and conditioned fear-related behavior in mice " on BioRxiv
April 1st, 2019 - Our review of recently developed G protein-biased kappa opioid receptor agonists and their therapeutic potential has been accepted for publication in Frontiers in Pharmacology.
February 27th, 2019 - Our paper describing how different methods for euthanasia influence basal MAPK activity in male and female mice has been accepted for publication in Frontiers in Cellular Neuroscience.
February 4th, 2019 - Our paper describing how repeated use of the psychoactive substance ethylphenidate impacts neurochemistry and reward learning in adolescent male and female mice has been accepted for publication in Frontiers in Neuroscience.
January 11th, 2019 - Our paper in collaboration with the Fai lab providing "Critical evaluation of TRPA1-mediated locomotive behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery." has been accepted for publication in Scientific Reports.
Disclaimer of opinion
The information, statements and opinions presented on the the Van Rijn lab website are solely expressed by Dr. van Rijn and do not necessarily represent views held by Purdue University.